Mouse IL7R/CD127 ELISA Kit PicoKine® | Boster EK0714 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL7R/CD127 ELISA Kit PicoKine®

catalog :

EK0714

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0714

Product Name :

Mouse IL7R/CD127 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL7R/CD127 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il7r in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

IL7R

Uniprot ID :

P16872

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E21-D239

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-7 receptor subunit alpha

Synonyms :

Interleukin-7 receptor subunit alpha;IL-7 receptor subunit alpha;IL-7R subunit alpha;IL-7R-alpha;IL-7RA;CD127;Il7r;

Protein Name :

Interleukin-7 receptor subunit alpha

Molecular Weight :

51605 MW

Protein Function :

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Spleen, thymus and fetal liver.

Sequence Similarities :

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Background :

The interleukin-7 receptor (IL7R) is a protein found on the surface of cells. It is mapped to 5p13.2. The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. IL7R has been shown to play a critical role in the development of immune cells called lymphocytes-specifically in a process known as V (D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. What's more, IL7R antagonism is efficacious in treatment of EAE through its effects on Th17 cells and is a potential treatment for MS.

Research Category :

Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage