Mouse B7-1/CD80 ELISA Kit PicoKine® | Boster EK0708 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse B7-1/CD80 ELISA Kit PicoKine®

catalog :

EK0708

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0708

Product Name :

Mouse B7-1/CD80 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse B7-1/CD80 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Cd80 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CD80

Uniprot ID :

Q00609

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D37-K245

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

T-lymphocyte activation antigen CD80

Synonyms :

T-lymphocyte activation antigen CD80;Activation B7-1 antigen;B7;CD80;Cd80;B7;

Protein Name :

T-lymphocyte activation antigen CD80

Molecular Weight :

34590 MW

Protein Function :

Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.

Sequence Similarities :

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Background :

The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. The cDNA for B7-1 predicts a type I membrane protein, i.e., one synthesized with a signal peptide that is cleaved upon translocation across the endoplasmic membrane. The protein is predicted to contain 2 extracellular domains structurally similar to those of Ig, a hydrophobic transmembrane region, and a short cytoplasmic domain. The CD80 and CD86 (601020) genes encode B7-1 and B7-2, respectively, which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4. The standard product used in this kit is recombinant B7-1, D37—K245, which is composed of two single chains acids with the dipolymer.

Research Category :

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Myeloid, Stem Cells