Human TNFRSF7/CD27 ELISA Kit PicoKine® | Boster EK0698 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF7/CD27 ELISA Kit PicoKine®

catalog :

EK0698

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0698

Product Name :

Human TNFRSF7/CD27 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TNFRSF7/CD27 ELISA Kit PicoKine® (96 Tests). Quantitate Human CD27 in cell culture supernatants and serum. Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD27

Uniprot ID :

P26842

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T21-I192

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

CD27 antigen

Synonyms :

CD27 antigen;CD27L receptor;T-cell activation antigen CD27;T14;Tumor necrosis factor receptor superfamily member 7;CD27;CD27;TNFRSF7;

Protein Name :

CD27 antigen

Molecular Weight :

29137 MW

Protein Function :

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Found in most T-lymphocytes.

Sequence Similarities :

Contains 3 TNFR-Cys repeats.

Background :

CD27 antigen, also called CD27 or TNFRSF7 is a tumor necrosis factor receptor. This gene is mapped to 12p13.31. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Research Category :

Adaptive Immunity, Cancer, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, Tnf Superfamily, Tumor Immunology