Human CCL28 ELISA Kit PicoKine® | Boster EK0690 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CCL28 ELISA Kit PicoKine®

catalog :

EK0690

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0690

Product Name :

Human CCL28 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CCL28 ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL28 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL28

Uniprot ID :

Q9NRJ3

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: I23-Y127

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 28

Synonyms :

C-C motif chemokine 28;Mucosae-associated epithelial chemokine;MEC;Protein CCK1;Small-inducible cytokine A28;CCL28;SCYA28;

Protein Name :

C-C motif chemokine 28

Molecular Weight :

14280 MW

Protein Function :

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

Subcellular Localization :

Secreted.

Tissue Specificity :

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

Background :

CCL28, also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. It is mapped to 5p12. The tumor hypoxia promotes the recruitment of regulatory T (Treg) cells through induction of expression of the chemokine CCL28, which in turn promotes tumor tolerance and angiogenesis. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues. It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans.

Research Category :

Cytokines, Immunology, Innate Immunity, Metabolism, Obesity