Human TNFRSF17/BCMA ELISA Kit PicoKine® | Boster EK0661 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF17/BCMA ELISA Kit PicoKine®

catalog :

EK0661

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0661

Product Name :

Human TNFRSF17/BCMA ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TNFRSF17/BCMA ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF17 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF17

Uniprot ID :

Q02223

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-A54

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 17

Synonyms :

Tumor necrosis factor receptor superfamily member 17;B-cell maturation protein;CD269;TNFRSF17;BCM, BCMA;

Protein Name :

Tumor necrosis factor receptor superfamily member 17

Molecular Weight :

20165 MW

Protein Function :

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Subcellular Localization :

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.

Tissue Specificity :

Expressed in mature B-cells, but not in T- cells or monocytes.

Sequence Similarities :

Contains 1 TNFR-Cys repeat.

Background :

TNFRSF17 (Tumor necrosis factor receptor superfamily member 17), also called BCMA, is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily and is mapped to 16p13.13. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Research Category :

Antiviral Signaling, Cancer, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Signal Transduction