Human AFP/Alpha-fetoprotein ELISA Kit PicoKine® | Boster EK0651 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human AFP/Alpha-fetoprotein ELISA Kit PicoKine®

catalog :

EK0651

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0651

Product Name :

Human AFP/Alpha-fetoprotein ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human AFP/Alpha-fetoprotein ELISA Kit PicoKine® (96 Tests). Quantitate Human AFP in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

AFP

Uniprot ID :

P02771

Immunogen :

Expression system for standard: NS0; Immunogen sequence: R19-V609

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

78 pg/ml - 5,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Alpha-fetoprotein

Synonyms :

Alpha-fetoprotein;Alpha-1-fetoprotein;Alpha-fetoglobulin;AFP;HPAFP;

Protein Name :

Alpha-fetoprotein

Molecular Weight :

68678 MW

Protein Function :

Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

Subcellular Localization :

Secreted.

Tissue Specificity :

Plasma. Synthesized by the fetal liver and yolk sac.

Background :

Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene. The AFP gene is located on the q arm of chromosome 4 (4q25). AFP is the most abundant plasma protein found in the human fetus. Plasma levels decrease rapidly after birth but begin decreasing prenatally starting at the end of the first trimester. Normal adult levels are usually achieved by the age of 8 to 12 months. The function of AFP in adult humans is unknown; however, in rodents it binds estradiol to prevent the transport of this hormone across the placenta to the fetus. The main function of this is to prevent the virilization of female fetuses. As human AFP does not bind estrogen, its function in humans is less clear.

Research Category :

Cancer, Cardiovascular, Developmental Biology, Organogenesis, Serum Proteins, Tumor Antigens, Tumor Biomarkers