Mouse Amphiregulin(AR) ELISA Kit PicoKine® | Boster EK0591 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Amphiregulin(AR) ELISA Kit PicoKine®

catalog :

EK0591

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0591

Product Name :

Mouse Amphiregulin(AR) ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Amphiregulin (AR) ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Areg in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

AREG

Uniprot ID :

P31955

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: V100-A248

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Amphiregulin

Synonyms :

Amphiregulin;AR;Schwannoma-derived growth factor;SDGF;Areg;Sdgf;

Protein Name :

Amphiregulin

Molecular Weight :

27549 MW

Protein Function :

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subcellular Localization :

Membrane; Single-pass membrane protein.

Sequence Similarities :

Belongs to the amphiregulin family.

Background :

Amphiregulin, also known as AREG, is a protein that is encoded by the AREG gene. The protein encoded by this gene is a member of the epidermal growth factor family. This gene is mapped to mouse chromosome 5. It is an autocrine growth factor as well as a mitogen forastrocytes, Schwann cells, fibroblasts. Amphiregulin is related to toepidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the epidermal growth factor receptor to promote the growth of normal epithelial cells. It has been found that transgene integration and subsequent expression of Amphiregulin in basal keratinocytes correlated with a psoriasis-like skin phenotype, and its expression was increased in parallel with typical Th2 cytokines. Amphiregulin is also an important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation but not for any earlier or later developmental stages, and it can enhance resistance to nematodes.

Research Category :

Cancer, Growth Factors, Growth Factors/Hormones, Signal Transduction