Human TNF Beta/Lymphotoxin-alpha ELISA Kit PicoKine® | Boster EK0584 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNF Beta/Lymphotoxin-alpha ELISA Kit PicoKine®

catalog :

EK0584

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0584

Product Name :

Human TNF Beta/Lymphotoxin-alpha ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TNF Beta ELISA Kit PicoKine® (96 Tests). Quantitate Human LTA in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 5pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LTA

Uniprot ID :

P01374

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: L35-L205

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<5 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Lymphotoxin-alpha

Synonyms :

Lymphotoxin-alpha;LT-alpha;TNF-beta;Tumor necrosis factor ligand superfamily member 1;LTA;TNFB, TNFSF1;

Protein Name :

Lymphotoxin-alpha

Molecular Weight :

22297 MW

Protein Function :

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

Subcellular Localization :

Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Sequence Similarities :

Belongs to the tumor necrosis factor family.

Background :

Tumor necrosis factor-beta (TNF-beta), previously called lymphotoxin-alpha (LTA), is a cytokine produced by lymphocytes. TNF-alpha and TNF-beta share 35% identity and 50% homology in the amino acid sequence. The substance LTA mediates a wide variety of inflammatory, immunostimulatory, and antiviral responses. LTA is associated with susceptibility to myocardial infarction, asthma and other diseases. The LTA gene is located on human chromosome 6. The standard product used in this kit is recombinant protein, consisting of 172 amino acids with the molecular mass of 18.8KDa.

Research Category :

Biochemicals, Chemical Type, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Lipid Signaling, Metabolic Signaling Pathways, Metabolism, Pathways And Processes