Mouse LIF ELISA Kit PicoKine® | Boster EK0580 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse LIF ELISA Kit PicoKine®

catalog :

EK0580

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0580

Product Name :

Mouse LIF ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse LIF ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Lif in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Lif

Uniprot ID :

P09056

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S24-F203

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Leukemia inhibitory factor

Synonyms :

Leukemia inhibitory factor;LIF;Differentiation-stimulating factor;D factor;Lif;

Protein Name :

Leukemia inhibitory factor

Molecular Weight :

22287 MW

Protein Function :

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

Subcellular Localization :

Secreted.

Background :

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.

Research Category :

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Differentiation, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Neurogenesis, Neurology Process, Neuroscience, Transcription, Tumor Suppressors