Human CD30/TNFRSF8 ELISA Kit PicoKine® | Boster EK0569 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD30/TNFRSF8 ELISA Kit PicoKine®

catalog :

EK0569

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0569

Product Name :

Human CD30/TNFRSF8 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CD30/TNFRSF8 ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF8 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF8

Uniprot ID :

P28908

Immunogen :

Expression system for standard: NS0; Immunogen sequence: F19-K379

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 8

Synonyms :

Tumor necrosis factor receptor superfamily member 8;CD30L receptor;Ki-1 antigen;Lymphocyte activation antigen CD30;CD30;TNFRSF8;CD30, D1S166E;

Protein Name :

Tumor necrosis factor receptor superfamily member 8

Molecular Weight :

63747 MW

Protein Function :

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Sequence Similarities :

Contains 6 TNFR-Cys repeats.

Background :

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. This gene is mapped to 1p36.22. CD30 is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. CD30 mast cell activation represents an IgE-independent activation pathway, which is important for understanding cutaneous inflammation associated with mast cells. In addition to those, CD30 is also associated with anaplastic large cell lymphoma.

Research Category :

Cancer, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Receptors, Tnf Superfamily, Tumor Biomarkers, Tumor Immunology