Human Cardiotrophin-1 / CTF1 ELISA Kit PicoKine® | Boster EK0563 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cardiotrophin-1 / CTF1 ELISA Kit PicoKine®

catalog :

EK0563

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0563

Product Name :

Human Cardiotrophin-1 / CTF1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Cardiotrophin-1 / CTF1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CTF1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CTF1

Uniprot ID :

Q16619

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S2-A201

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cardiotrophin-1

Synonyms :

Cardiotrophin-1;CT-1;CTF1;

Protein Name :

Cardiotrophin-1

Molecular Weight :

21227 MW

Protein Function :

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular Localization :

Secreted.

Tissue Specificity :

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Background :

Cardiotrophin-1 (CT-1) is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), interleukin-6 (IL6), and interleukin-11 (IL11). And the CT-1 gene is mapped to 1p21-p13. The human CT-1 protein contains 201 amino acids and shares 80% amino acid identity with the 203-amino acid mouse CT-1 sequence; however, unlike the mouse protein, human CT-1 has 2 rather than 1 cys and has no N-glycosylation site. Despite lacking a signal sequence, secreted CT-1 and mouse CT-1 induce cardiac myocyte hypertrophy in cell culture and bind to both mouse and human LIFR but not to OSMR. Furthermore, A 1.7-kb CT-1 transcript was detected at high levels in heart, skeletal muscle, prostate, and ovary. Low levels were detected in lung, kidney, pancreas, thymus, testis, and small intestine, with little or no expression detected in brain, placenta, spleen, colon, and peripheral blood leukocytes. And it was also observed strong expression in fetal lung and kidney.

Research Category :

Atherosclerosis, Cardiovascular, Cytokines, Diabetes Associated, Energy Metabolism, Energy Transfer Pathways, Hypertrophy, Immunology, Innate Immunity, Lipid Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways And Processes, Signal Transduction