Mouse E-Cadherin/CDH1/Cadherin-1 ELISA Kit PicoKine® | Boster EK0562 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse E-Cadherin/CDH1/Cadherin-1 ELISA Kit PicoKine®

catalog :

EK0562

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0562

Product Name :

Mouse E-Cadherin/CDH1/Cadherin-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse E-Cadherin 1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Cdh1 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 15pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CDH1

Uniprot ID :

P09803

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D157-V709

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cadherin-1

Synonyms :

Cadherin-1;ARC-1;Epithelial cadherin;E-cadherin;Uvomorulin;CD324;E-Cad/CTF1;E-Cad/CTF2;E-Cad/CTF3;Cdh1;

Protein Name :

Cadherin-1

Molecular Weight :

98256 MW

Protein Function :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).

Subcellular Localization :

Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome . Golgi apparatus, trans-Golgi network . Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).

Tissue Specificity :

Non-neural epithelial tissues.

Background :

E-Cadherin, also called Cadherin 1 (CDH1), Uvomorulin or calcium-dependent ashesion protein, epithelial. E-cadherin is a Ca (2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. The gene spans a region of approximately 100 kb, and its location on chromosome 16q22.1. It contains 16 exons and a 65-kb-long intron 2. E-cadherin gene mutations may contribute to the development of diffusely growing gastric carcinomas. E-cadherin plays a central part in the process of epithelial morphogenesis and acts as a strong invasion suppressor in experimental tumor cell systems.

Research Category :

Cadherins, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Adhesion, Cytoskeleton / Ecm, Invasion/Microenvironment, Signal Transduction, Signaling Pathway