Mouse ACE/Cd143 ELISA Kit PicoKine® | Boster EK0558 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse ACE/Cd143 ELISA Kit PicoKine®

catalog :

EK0558

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0558

Product Name :

Mouse ACE/Cd143 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse ACE/Cd143 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ace in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

ACE

Uniprot ID :

P09470

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L35-Q1264

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.8 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Angiotensin-converting enzyme

Synonyms :

Angiotensin-converting enzyme;ACE;3.2.1.-;3.4.15.1;Dipeptidyl carboxypeptidase I;Kininase II;CD143;Angiotensin-converting enzyme, soluble form;Ace;Dcp1;

Protein Name :

Angiotensin-converting enzyme

Molecular Weight :

150918 MW

Protein Function :

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

Subcellular Localization :

Angiotensin-converting enzyme, soluble form: Secreted .

Tissue Specificity :

Testis-specific isoform is expressed in spermatocytes, adult testis.

Background :

Angiotensin-converting enzyme (ACE), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, ACE was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.

Research Category :

Cancer, Cancer Metabolism, Cardiovascular, Cell Biology, Cofactors, Vitamins / Minerals, Hematopoietic Progenitors, Metabolism, Metabolism Processes, Metalloprotease, Pathways And Processes, Proteolysis / Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Serum Proteins, Signal Transduction, Stem Cells, Surface Molecules, Vasculature, Vitamins / Minerals