Human TRAILR3/TNFRSF10C ELISA Kit PicoKine® | Boster EK0533 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TRAILR3/TNFRSF10C ELISA Kit PicoKine®

catalog :

EK0533

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0533

Product Name :

Human TRAILR3/TNFRSF10C ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TRAILR3/TNFRSF10C ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF10C in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 12pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF10C

Uniprot ID :

O14798

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A26-A236

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<12 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

TNF receptor superfamily member 10c

Synonyms :

Tumor necrosis factor receptor superfamily member 10C; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD263; TNFRSF10C; DCR1, LIT, TRAILR3, TRID; UNQ321/PRO366;

Protein Function :

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Subcellular Localization :

Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity :

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Background :

TRAILR3/TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. TRAILR3 gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Research Category :

Apoptosis, Cancer, Cell Biology, Cell Death, Cytokines, Immunology, Innate Immunity, Receptors