Mouse sTNFsR II ELISA Kit PicoKine® | Boster EK0531 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse sTNFsR II ELISA Kit PicoKine®

catalog :

EK0531

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0531

Product Name :

Mouse sTNFsR II ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse sTNFsR II ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfrsf1b in cell culture supernatants and serum. Sensitivity: 1pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TNFRSF1B

Uniprot ID :

P25119

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V23-G258

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 1B

Synonyms :

Tumor necrosis factor receptor superfamily member 1B;Tumor necrosis factor receptor 2;TNF-R2;Tumor necrosis factor receptor type II;TNF-RII;TNFR-II;p75;p80 TNF-alpha receptor;CD120b;Tnfrsf1b;Tnfr-2, Tnfr2;

Protein Name :

Tumor necrosis factor receptor superfamily member 1B

Molecular Weight :

50320 MW

Protein Function :

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Background :

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Research Category :

Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Growth Factors/Hormones, Receptors, Signal Transduction