Mouse TNFsR I ELISA Kit PicoKine® | Boster EK0529 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TNFsR I ELISA Kit PicoKine®

catalog :

EK0529

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0529

Product Name :

Mouse TNFsR I ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TNFsR I ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfrsf1a in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Tnfrsf1a

Uniprot ID :

P25118

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L30-A212

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 1A

Synonyms :

Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor 1;TNF-R1;Tumor necrosis factor receptor type I;TNF-RI;TNFR-I;p55;p60;CD120a;Tnfrsf1a;Tnfr-1, Tnfr1;

Protein Name :

Tumor necrosis factor receptor superfamily member 1A

Molecular Weight :

50130 MW

Protein Function :

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis (By similarity).

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane ; Single-pass type I membrane protein .

Background :

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNF alpha). The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. And this protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.

Research Category :

Signal Transduction