Monkey primate TIMP-3 ELISA Kit PicoKine® | Boster EK0523-PR product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Monkey primate TIMP-3 ELISA Kit PicoKine®

catalog :

EK0523-PR

quantity :

96 wells/kit, with removable strips.

price :

400 USD

more info or order :

Boster product webpage

citations: 1

Reference
Zheng Z, Jin X, Zhu M, Li C, Zhu F, Li W, et al. [Association between -1296T/C and -915A/G polymorphisms of matrix metalloproteinase inhibitor-3 gene and atherosclerotic cerebral infarction in an ethnic Han Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014;31:719-24 pubmed publisher

product information

SKU :

EK0523-PR

Product Name :

Monkey primate TIMP-3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

400 USD

Description :

Monkey primate TIMP-3 ELISA Kit PicoKine® (96 Tests). Quantitate Monkey TIMP3 in cell culture supernatants, serum, plasma (heparin, EDTA) and saliva. Sensitivity: 2pg/ml.

Reactivity :

Monkey

Application :

ELISA

Gene Name :

TIMP3

Uniprot ID :

P35625

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C24-P211

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and saliva

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Metalloproteinase inhibitor 3

Synonyms :

Metalloproteinase inhibitor 3;Protein MIG-5;Tissue inhibitor of metalloproteinases 3;TIMP-3;TIMP3;

Protein Name :

Metalloproteinase inhibitor 3

Molecular Weight :

24145 MW

Protein Function :

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix.

Sequence Similarities :

Belongs to the protease inhibitor I35 (TIMP) family.

Background :

The tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy (SFD).

Research Category :

Angiogenesis, Apoptosis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Neuroscience, Protease Inhibitors, Proteolysis / Ubiquitin, Sensory System, Signal Transduction, Visual System

more info or order :

Boster product webpage