ELISA/assay

Rat TGF Beta 1 ELISA Kit PicoKine®

EK0514

96 wells/kit, with removable strips.

Rat TGF Beta 1 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

Rat TGF Beta 1 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Tgfb1 in cell culture supernatants, serum, plasma (EDTA) and urine. Sensitivity: 1pg/ml.

Rat

Bovine, Canine, Monkey, Rabbit

ELISA

TGFB1

P17246

Expression system for standard: CHO; Immunogen sequence: A279-S390

There is cross-reactivity with TGFbeta2, TGFbeta3, TGFbeta5<1%.

15.6 pg/ml - 1,000 pg/ml

<1 pg/ml

cell culture supernatants, serum, plasma (EDTA) and urine

monoclonal antibody from mouse, polyclonal antibody from goat

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Transforming growth factor beta-1

Transforming growth factor beta-1;TGF-beta-1;Latency-associated peptide;LAP;Tgfb1;

Transforming growth factor beta-1

44329 MW

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity).

Secreted, extracellular space, extracellular matrix .

Abundant in the bone matrix.

Transforming growth factor-beta1 (TGF-beta1) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. TGFbeta1 is known for its potent and diverse biological effects, including immune regulation, and cell growth and differentiation. TGFbeta1 is also an important mediator of bone remodeling. TGFbeta1, a potent keratinocyte growth inhibitor, has been shown to be overexpressed in keratinocytes in certain inflammatory skin diseases and has been thought to counteract the effects of other growth factors at the site of inflammation. TGF-beta1, a multifunctional cytokine with fibrogenic properties, has been implicated in the pathogenesis of the vascular and target organ complications of hypertension. TGF-beta1 may also regulate blood pressure via stimulation of endothelin-1 and/or renin secretion. TGFbeta1 is secreted as a latent form, which consists of its mature form and a latency-associated peptide (beta1-LAP) in either the presence or the absence of additional latent TGF-beta1-binding protein. The standard product used in this kit is recombinant TGFbeta1 with the molecular mass of 25KDa.

Angiogenesis, Cancer, Cancer Metabolism, Cardiovascular, Co-Factors, Cofactors, Vitamins / Minerals, Developmental Biology, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Metabolism, Metabolism Processes, Organogenesis, Pathways And Processes, Response To Hypoxia, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tgf Beta