Rat SCF/KITLG/Kit ligand ELISA Kit PicoKine® | Boster EK0508 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat SCF/KITLG/Kit ligand ELISA Kit PicoKine®

catalog :

EK0508

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0508

Product Name :

Rat SCF/KITLG/Kit ligand ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat SCF ELISA Kit PicoKine® (96 Tests). Quantitate Rat Kitlg in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

Kitlg

Uniprot ID :

P21581

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Q26-A190

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Kit ligand

Synonyms :

Kit ligand;Hematopoietic growth factor KL;Mast cell growth factor;MGF;Stem cell factor;SCF;c-Kit ligand;Soluble KIT ligand;sKITLG;Kitlg;Kitl, Mgf;

Protein Name :

Kit ligand

Molecular Weight :

30712 MW

Protein Function :

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Subcellular Localization :

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Background :

Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117). It is mapped to 12q21.32. SCF was primarily expressed by perivascular cells throughout the bone marrow, and it plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF can exist both as a transmembrane protein and a soluble protein. This gene plays an important role in the hematopoiesis during embryonic development. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. In addition to it, SCF can promote mast cell adhesion, migration, proliferation, and survival. It also promotes the release of histamine and tryptase, which are involved in the allergic response.

Research Category :

Cytokines, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Immunology, Innate Immunity, Stem Cells, Surface Molecules