Mouse Rantes ELISA Kit PicoKine® | Boster EK0495 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Rantes ELISA Kit PicoKine®

catalog :

EK0495

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0495

Product Name :

Mouse Rantes ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Rantes ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl5 in cell culture supernatants. serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CCL5

Uniprot ID :

P30882

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S24-S91

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 5

Synonyms :

C-C motif chemokine 5;MuRantes;SIS-delta;Small-inducible cytokine A5;T-cell-specific protein RANTES;Ccl5;Scya5;

Protein Name :

C-C motif chemokine 5

Molecular Weight :

10071 MW

Protein Function :

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.

Subcellular Localization :

Secreted.

Tissue Specificity :

T-cell and macrophage specific.

Background :

Rantes (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Peripheral blood mononuclear cells or CD4 (+) lymphocytes obtained from different individuals have wide variations in their ability to secrete RANTES. The Rantes gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. Rantes is expressed by cultured T cell lines that are Ag specific and growth factor dependent.

Research Category :

Antiviral Signaling, Atherosclerosis, Cardiovascular, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Vascular Inflammation