ELISA/assay

Human PLGF PicoKine ELISA Kit

EK0490

96 wells/kit

380 USD

Human PLGF PicoKine ELISA Kit

380 USD

Expression system for standard: E.coli; Immunogen sequence: A21-R149

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Placental Growth Factor

96 wells/kit

Human

ELISA

The protein, also called PGF, is 149 amino acids long and shares 53% identity with the platelet-derived growth factor-like region of human VPF. And the N-glycosylated PLGF protein is secreted into the medium and that it functions as a dimer1. The PLGF gene is mapped to 14q24-q31. There are 3 isoforms of PGF, designated PGF1, PGF2, and PGF3. Only PGF2 is able to bind heparin. Additionally, PGF regulates inter- and intramolecular cross-talk between the VEGF receptor tyrosine kinases FLT1 and FLK12. It also can stimulate angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to VEGF3.

There is no detectable cross-reactivity with other relevant proteins.

Placenta growth factor

PGF

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

Placenta growth factor

signal transduction growth factors/hormones vegf cancer cancer metabolism response to hypoxia kits/ lysates/ other elisa kits growth factors and hormones elisa kits metabolism pathways and processes metabolism processes types of disease

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Placenta growth factor;PlGF;PGF;PGFL, PLGF;

While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

P49763