Rat PDGF-AB PicoKine ELISA Kit | Boster EK0485 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat PDGF-AB PicoKine ELISA Kit

catalog :

EK0485

quantity :

96 wells/kit

price :

320 USD

more info or order :

Boster product webpage

product information

sku :

EK0485

name :

Rat PDGF-AB PicoKine ELISA Kit

price :

320 USD

immunogen :

Expression system for standard: E.coli; Immunogen sequence: (R86-K204)+(S74-T182)

description :

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat PDGF-AB

size :

96 wells/kit

reactivity :

Rat

applications :

ELISA

background :

The platelet-derived growth factor(PDGF) is a mitogen derived from human platelets consisting of two related polypeptides termed A and B chains. The genes for PDGF A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines. Normal human endothelial cells in culture express the B chain of PDGF, and that endothelial-derived PDGF B chain is synthesized as a predicted precursor polypeptide of Mr 27,281. The entire B chain of PDGF is highly(96%) homologous to a portion of p28sis, the transforming protein of simian sarcoma virus(SSV). It has been suggested that p28sis exerts its transforming potential by mimicking the growth promoting activity of PDGF and stimulating the cell in an autocrine manner. PDGF A-chain precursor polypeptide is assigned to the proximal long arm of chromosome 7, band q11.23. The human homolog(PDGF B-chain/c-sis) of the transforming gene of simian sarcoma virus is assigned to chromosome 22. The standard product used in this kit is recombinant rat PDGF-AB(A chain Ser87-Arg196; B chain Ser74-Thr182) with the molecular mass of 24.8KDa.

cross reactivity :

There is no detectable cross-reactivity with other relevant proteins.

gene full name :

platelet-derived growth factor beta polypeptide,platelet-derived growth factor alpha polypeptide

gene name :

PDGFB, PDGFA; Pdgfb

protein function :

Pdgfa: Growth factor that plays an essential role in theregulation of embryonic development, cell proliferation, cellmigration, survival and chemotaxis. Potent mitogen for cells ofmesenchymal origin. Required for normal lung alveolar septumformation during embryogenesis, normal development of thegastrointestinal tract, normal development of Leydig cells andspermatogenesis. Required for normal oligodendrocyte developmentand normal myelination in the spinal cord and cerebellum. Plays animportant role in wound healing. Signaling is modulated by theformation of heterodimers with PDGFB (By similarity).

protein name :

Platelet-derived growth factor subunit B,Platelet-derived growth factor subunit A

research category :

cardiovascular blood serum proteins platelets signal transduction growth factors/hormones pdgf immunology secreted molecules secreted molecules cancer growth factors atherosclerosis vascular inflammation inflammatory mediators neuroscience neurology process neuroregeneration cancer metabolism response to hypoxia pathways and processes metabolism processes types of disease

storage :

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

subcellular localization :

Pdgfa: Secreted. Note: Released by platelets uponwounding.

synonyms :

Platelet derived growth factor, B polypeptide ;Platelet-derived growth factor subunit B ;Pdgfb ;rCG_59494 ;

uniprot id :

G3V882

more info or order :

Boster product webpage