Mouse OPG PicoKine ELISA Kit | Boster EK0481 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse OPG PicoKine ELISA Kit

catalog :

EK0481

quantity :

96 wells/kit

price :

380 USD

more info or order :

Boster product webpage

product information

sku :

EK0481

name :

Mouse OPG PicoKine ELISA Kit

price :

380 USD

immunogen :

Expression system for standard: NSO; Immunogen sequence: E22-L401

description :

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse OPG

size :

96 wells/kit

reactivity :

Mouse

applications :

ELISA

background :

Osteoprotegerin(OPG) is identical to osteoclastogenesis inhibitory factor(OCIF), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. OPG is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Osteoprotegerin is an independent risk factor for the progression of atherosclerosis and onset of cardiovascular disease. It can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. OPG system may play a critical role in the development of osteolytic bone disease in multiple myeloma and that targeting this system may have therapeutic potential. OPG also plays a role in the vascular system.

cross reactivity :

There is no detectable cross-reactivity with other relevant proteins.

gene full name :

Tumor necrosis factor receptor superfamily member 11B

gene name :

TNFRSF11B; Tnfrsf11b

protein function :

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

protein name :

Tumor necrosis factor receptor superfamily member 11B

research category :

cardiovascular blood immunology innate immunity cytokines tnf superfamily signal transduction cytoskeleton / ecm extracellular matrix structures bone cardiovascular atherosclerosis vascular inflammation inflammatory mediators metabolism types of disease obesity

sequence similarities :

Contains 2 death domains.

storage :

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

subcellular localization :

Secreted.

synonyms :

Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;Tnfrsf11b;Ocif, Opg;

tissue specificity :

Highly expressed in liver, lung, stomach, intestines and calvaria. Highly expressed in decidua and placenta, and in embryo.

uniprot id :

O08712

more info or order :

Boster product webpage