Boster

ELISA/assay

Human OPG PicoKine ELISA Kit

EK0480

96 wells/kit

320 USD

EK0480

Human OPG PicoKine ELISA Kit

320 USD

Expression system for standard: NSO; Immunogen sequence: E22-L401

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human OPG

96 wells/kit

Human

ELISA

Osteoprotegerin(OPG) is identical to osteoclastogenesis inhibitory factor(OCIF), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. OPG is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Osteoprotegerin is an independent risk factor for the progression of atherosclerosis and onset of cardiovascular disease. It can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. OPG system may play a critical role in the development of osteolytic bone disease in multiple myeloma and that targeting this system may have therapeutic potential. OPG also plays a role in the vascular system. The standard product used in this kit is recombinant OPG, a 55KDa glycoprotein.

There is no detectable cross-reactivity with other relevant proteins.

Tumor necrosis factor receptor superfamily member 11B

TNFRSF11B

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Tumor necrosis factor receptor superfamily member 11B

cardiovascular blood immunology innate immunity cytokines tnf superfamily signal transduction cytoskeleton / ecm extracellular matrix structures bone cardiovascular atherosclerosis vascular inflammation inflammatory mediators metabolism types of disease obesity

Contains 2 death domains.

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Secreted.

Tumor necrosis factor receptor superfamily member 11B;Osteoclastogenesis inhibitory factor;Osteoprotegerin;TNFRSF11B;OCIF, OPG;

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

O00300