Boster

ELISA/assay

Human OSM/Oncostatin M PicoKine ELISA Kit

EK0478

96 wells/kit

369 USD

EK0478

Human OSM/Oncostatin M PicoKine ELISA Kit

369 USD

Expression system for standard: E.coli; Immunogen sequence: A26R-220

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human OSM/Oncostatin M

96 wells/kit

Human

ELISA

OSM(Oncostatin M) is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. The OSM gene is mapped on 22q12.2. Of these cytokines it most closely resembles leukemia inhibitory factor(LIF) in both structure and function. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR.

There is no detectable cross-reactivity with other relevant proteins.

Oncostatin-M

OSM

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Oncostatin-M

immunology innate immunity cytokines interleukins immunology il6 related signal transduction signaling pathway nuclear signaling stats epigenetics and nuclear signaling nuclear signaling pathways

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Secreted.

Oncostatin-M;OSM;OSM;

P13725