Human MMP-8 PicoKine ELISA Kit | Boster EK0464 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human MMP-8 PicoKine ELISA Kit

catalog :

EK0464

quantity :

96 wells/kit

price :

430 USD

more info or order :

Boster product webpage

product information

sku :

EK0464

name :

Human MMP-8 PicoKine ELISA Kit

price :

430 USD

immunogen :

Expression system for standard: NSO; Immunogen sequence: F21-G467

description :

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human MMP-8

size :

96 wells/kit

reactivity :

Human

applications :

ELISA

background :

Matrix metalloproteinase 8(MMP8) also called neutrophil collagenase. Neutrophil collagenase, a member of the family of matrix metalloproteinases, is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8, an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The human neutrophil collagenase(HNC) cDNA clone has been sequenced and shown to encode a 467-residue protein. Neutrophil collagenase has been found to possess 57% identity with the deduced protein sequence for fibroblast collagenase with 72% chemical similarity. Certain regions of the molecule, including the putative zinc-binding region, are highly conserved. When compared with the published sequence for fibroblast collagenase, neutrophil collagenase contains four additional sites for glycosylation. The standard product used in this kit is natural, isolating from human MMP-8. The detected MMP-8 includes zymogen and active enzyme.

cross reactivity :

There is no detectable cross-reactivity with other relevant proteins.

gene full name :

Neutrophil collagenase

gene name :

MMP8

protein function :

Can degrade fibrillar type I, II, and III collagens.

protein name :

Neutrophil collagenase

research category :

cardiovascular angiogenesis adhesion / ecm matrix metalloproteinases mmp signal transduction cytoskeleton / ecm extracellular matrix ecm enzymes cancer invasion/microenvironment mmps cell biology proteolysis / ubiquitin proteolytic enzymes metalloprotease tumor biomarkers cardiovascular atherosclerosis vascular inflammation leukocyte recruitment kits/ lysates/ other elisa kits atherosclerotic proteins elisa kits tumor biomarkers elisa kits

sequence similarities :

Belongs to the peptidase M10A family.

storage :

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

subcellular localization :

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.

synonyms :

Neutrophil collagenase;3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL;MMP8;CLG1;

tissue specificity :

Neutrophils

uniprot id :

P22894

more info or order :

Boster product webpage