ELISA/assay

Human MMP-7 PicoKine ELISA Kit

EK0463

96 wells/kit

430 USD

Human MMP-7 PicoKine ELISA Kit

430 USD

Expression system for standard: NSO; Immunogen sequence: L18-K267

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human MMP-7

96 wells/kit

Human

ELISA

Matrix metalloproteinase-7(MMP-7) previously called putative metalloproteinase I(PUMP1) or matrilysin. The PUMP1 gene has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The PUMP I protein has 267 amino acids and is significantly shorter than stromelysin or collagenase(477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. Matrilysin, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, matrilysin mRNA is regulated in a specific and distinct manner in normal and malignant tissues. Matrilysin has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined.1 Matrilysin is also a mediator of pulmonary fibrosis and a potential therapeutic target. The standard product used in this kit is recombinant human MMP-7, consisting of 250 amino acids with the molecular mass of 28KDa. The detected MMP-7 includes zymogen and active enzyme.

There is no detectable cross-reactivity with other relevant proteins.

Matrilysin

MMP7

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Matrilysin

cardiovascular angiogenesis adhesion / ecm matrix metalloproteinases mmp signal transduction cytoskeleton / ecm extracellular matrix ecm enzymes cancer invasion/microenvironment mmps cell biology proteolysis / ubiquitin proteolytic enzymes metalloprotease tumor biomarkers

Belongs to the peptidase M10A family.

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Secreted, extracellular space, extracellular matrix .

Matrilysin;3.4.24.23;Matrin;Matrix metalloproteinase-7;MMP-7;Pump-1 protease;Uterine metalloproteinase;MMP7;MPSL1, PUMP1;

P09237