Mouse MMP-3 PicoKine ELISA Kit | Boster EK0462 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse MMP-3 PicoKine ELISA Kit

catalog :

EK0462

quantity :

96 wells/kit

price :

380 USD

more info or order :

Boster product webpage

product information

sku :

EK0462

name :

Mouse MMP-3 PicoKine ELISA Kit

price :

380 USD

immunogen :

Expression system for standard: NSO; Immunogen sequence: Y18-C477

description :

Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse MMP-3

size :

96 wells/kit

reactivity :

Mouse

applications :

ELISA

background :

Matrix metalloproteinase-3(MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase(MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition.

cross reactivity :

There is cross-reactivity with MMP-10 approximately 2% and no detectable cross-reactivity with other MMPs.

gene full name :

Stromelysin-1

gene name :

MMP3; Mmp3

protein function :

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

protein name :

Stromelysin-1

research category :

cardiovascular angiogenesis adhesion / ecm matrix metalloproteinases mmp signal transduction cytoskeleton / ecm extracellular matrix ecm enzymes cancer invasion/microenvironment mmps cell biology proteolysis / ubiquitin proteolytic enzymes metalloprotease tumor biomarkers cardiovascular atherosclerosis thrombosis kits/ lysates/ other cell metabolism kits other metabolism assay elisa kits atherosclerotic proteins elisa kits developmental proteins elisa kits cancer proteins elisa kits protease inhibitors elisa kits

sequence similarities :

Belongs to the peptidase M10A family.

storage :

Store at 4ËšC for 6 months, at -20ËšC for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

subcellular localization :

Secreted, extracellular space, extracellular matrix .

synonyms :

Stromelysin-1;SL-1;3.4.24.17;EMS-2;Matrix metalloproteinase-3;MMP-3;Transin-1;Mmp3;

uniprot id :

P28862

more info or order :

Boster product webpage