Human CCL4/MIP-1 Beta ELISA Kit PicoKine® | Boster EK0450 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CCL4/MIP-1 Beta ELISA Kit PicoKine®

catalog :

EK0450

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0450

Product Name :

Human CCL4/MIP-1 Beta ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CCL4/MIP-1 Beta ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL4 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL4

Uniprot ID :

P13236

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A24-N92

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 4

Synonyms :

C-C motif chemokine 4;G-26 T-lymphocyte-secreted protein;HC21;Lymphocyte activation gene 1 protein;LAG-1;MIP-1-beta (1-69);Macrophage inflammatory protein 1-beta;MIP-1-beta;PAT 744;Protein H400;SIS-gamma;Small-inducible cytokine A4;T-cell activation protein 2;ACT-2;MIP-1-beta (3-69);CCL4;LAG1, MIP1B, SCYA4;

Protein Name :

C-C motif chemokine 4

Molecular Weight :

10212 MW

Protein Function :

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta (3-69) is also a ligand for CCR1 and CCR2 isoform B.

Subcellular Localization :

Secreted.

Sequence Similarities :

Belongs to the intercrine beta (chemokine CC) family.

Background :

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. the CCL4 gene was assigned to a slightly more distal location: 17q21-q23 rather than 17q11-q21.

Research Category :

Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage / Inflamm.