Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® | Boster EK0449 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine®

catalog :

EK0449

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0449

Product Name :

Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CCL3

Uniprot ID :

P10855

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A24-A92

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 3

Synonyms :

C-C motif chemokine 3;Heparin-binding chemotaxis protein;L2G25B;Macrophage inflammatory protein 1-alpha;MIP-1-alpha;SIS-alpha;Small-inducible cytokine A3;TY-5;Ccl3;Mip1a, Scya3;

Protein Name :

C-C motif chemokine 3

Molecular Weight :

10345 MW

Protein Function :

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in lung, spleen, and pancreas.

Background :

Chemokine (C-C motif) ligand 3 (CCL3), so known as Macrophage inflammatory protein-1alpha (MIP-1 alpha), is a protein that in humans is encoded by the CCL3 gene. It is a cytokine which belongs to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. This gene is mapped to 17q12. CCL3 plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. It has been found that the activation of CCR5 by CCL3 directly and independently activates a G-protein signaling pathway through GNAI2 and a tyrosine phosphorylation signaling pathway through JAK2.

Research Category :

Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage / Inflamm.