Mouse M-CSF ELISA Kit PicoKine® | Boster EK0445 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse M-CSF ELISA Kit PicoKine®

catalog :

EK0445

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0445

Product Name :

Mouse M-CSF ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse M-CSF ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Csf1 in cell culture supernatants, serum and plasma (EDTA). Sensitivity: 1pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CCL3

Uniprot ID :

P07141

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: K33-E262

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Macrophage colony-stimulating factor 1

Synonyms :

Macrophage colony-stimulating factor 1;CSF-1;MCSF;Processed macrophage colony-stimulating factor 1;Csf1;Csfm;

Protein Name :

Macrophage colony-stimulating factor 1

Molecular Weight :

60649 MW

Protein Function :

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Background :

M-CSF, also called CSF1, consists of a 14-amino acid peptide, longer than the usual 8-to-11 mer recognized by most CTLs. The M-CSF gene is mapped to 1p21-p13 and contains 10 exons and 9 introns spanning 20 kb1. Although it is a single-copy gene, its expression results in the synthesis of several mRNAs, ranging in size from about 1.5 to 4.5 kb2. There are 2 forms of M-CSF, with 224 and 522 amino acids, resulting from alternative splicing3. Furthermore, M-CSF has a role in development of the placenta. Uterine M-CSF concentration is regulated by a synergistic action of estradiol and progesterone. M-CSF is produced by uterine glandular epithelial cells. It had been found that FMS, the M-CSF receptor, is expressed in placenta and choriocarcinoma cell lines4.

Research Category :

Atherosclerosis, Cardiovascular, Cytokines, Immunology, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation