Human CCL8/MCP-2 ELISA Kit PicoKine® | Boster EK0442 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CCL8/MCP-2 ELISA Kit PicoKine®

catalog :

EK0442

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0442

Product Name :

Human CCL8/MCP-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CCL8/MCP-2 ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL8 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL8

Uniprot ID :

P80075

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Q24-P99

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 8

Synonyms :

C-C motif chemokine 8;HC14;Monocyte chemoattractant protein 2;Monocyte chemotactic protein 2;MCP-2;Small-inducible cytokine A8;MCP-2 (6-76);CCL8;MCP2, SCYA10, SCYA8;

Protein Name :

C-C motif chemokine 8

Molecular Weight :

11246 MW

Protein Function :

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2 (6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.

Subcellular Localization :

Secreted.

Tissue Specificity :

Highest expression found in the small intestine and peripheral blood cells. Intermediate levels seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels seen in the brain, liver, spleen and prostate.

Sequence Similarities :

Belongs to the intercrine beta (chemokine CC) family.

Background :

Chemokine (C-C motif) ligand 8, also known as monocyte chemoattractant protein 2 (MCP-2), is a protein that in humans is encoded by the CCL8 gene. CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. Monocyte chemotactic protein 2 (MCP-2) is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes.

Research Category :

Chemokines, Immunology, Innate Immunity, Macrophage / Inflamm.