Human Laminin ELISA Kit PicoKine® | Boster EK0434 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Laminin ELISA Kit PicoKine®

catalog :

EK0434

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0434

Product Name :

Human Laminin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Laminin ELISA Kit PicoKine® (96 Tests). Quantitate Human LAMA1; LAMB1; LAMC1 in cell culture supernatants, cell lysates and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LAMA1/LAMB1/LAMC1

Uniprot ID :

P25391

Immunogen :

Expression system for standard: from human fibroblasts

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates and serum

Capture/Detection Antibodies :

polyclonal antibody from rabbit, polyclonal antibody from rabbit

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Laminin subunit alpha-1

Synonyms :

Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; Laminin subunit beta-1; Laminin B1 chain; Laminin subunit gamma-1; LAMB2

Protein Name :

Laminin subunit alpha-1; Laminin subunit beta-1; Laminin subunit gamma-1

Molecular Weight :

337084 MW

Protein Function :

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix, basement membrane. Major component.

Background :

Laminin is a large basement membrane glycoprotein composed of three subunits designated the A, B1, and B2.1 Laminin has diverse biological functions, which include stimulating epithelial cell growth and differentiation. The nucleotide sequence of human laminin A chain has an open reading frame encoding 3075-amino acids. The human laminin A chain is at locus 18p11.3. The nucleotide sequence of the human laminin B1 reveals a 5358-base pair open reading frame that potentially codes for 1786 amino acids, including 20 amino acids of a presumptive signal peptide.2 The gene for the human laminin-B1 chain has been localized to chromosome 7, band q31. The B2 chain consists of six distinct domains, including two domains with alpha-helical, coiled-coil structures, two domains with cysteine-rich homologous repeats, and two globular domains. The amino acid sequences of the B2 and B1 chains demonstrate considerable homology. The human laminin B2 chain gene maps to the long arm of chromosome 1 in the band q31.

Research Category :

Angiogenesis, Cardiovascular, Cell Adhesion Proteins, Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Intermediate Filaments, Neuroscience, Signal Transduction