Human IL1R1/Il 1 Ri ELISA Kit PicoKine® | Boster EK0395 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL1R1/Il 1 Ri ELISA Kit PicoKine®

catalog :

EK0395

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0395

Product Name :

Human IL1R1/Il 1 Ri ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL1R1/Il 1 Ri ELISA Kit PicoKine® (96 Tests). Quantitate Human IL1R1 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL1R1

Uniprot ID :

P14778

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D21-T332

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-1 receptor type 1

Synonyms :

Interleukin-1 receptor type 1;IL-1R-1;IL-1RT-1;IL-1RT1;CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha;Interleukin-1 receptor type I;p80;CD121a;Interleukin-1 receptor type 1, membrane form;mIL-1R1;mIL-1RI;Interleukin-1 receptor type 1, soluble form;sIL-1R1;sIL-1RI;IL1R1;IL1R, IL1RA, IL1RT1;

Protein Name :

Interleukin-1 receptor type 1

Molecular Weight :

65402 MW

Protein Function :

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .

Sequence Similarities :

Belongs to the interleukin-1 receptor family.

Background :

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. IL1R1 along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses.

Research Category :

Atherosclerosis, Cardiovascular, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage, Vascular Inflammation