Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® | Boster EK0393 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

catalog :

EK0393

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0393

Product Name :

Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine® (96 Tests). Quantitate Rat Il1b in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

IL1B

Uniprot ID :

Q63264

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: V117-S268

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

interleukin 1, beta

Synonyms :

Interleukin 1 beta ;Interleukin-1 beta ;Il1b ;rCG_27107 ;

Protein Name :

Interleukin-1 beta

Molecular Weight :

30659 MW

Protein Function :

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Background :

The Interleukin 1 family is a group of 11 beta trefoil cytokines. Interleukin-1, produced mainly by blood monocytes, mediates the panoply of host reactions collectively known as acute phase response . Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta belongs to proinflammatory cytokines, promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular cell adhesion molecule-1 (VCAM-1) on hepatic sinusoidal endothelium (HSE).

Research Category :

Atherosclerosis, Cardiovascular, Cytokines, Immunology, Innate Immunity, Interleukins, Metabolism, Obesity, Vascular Inflammation