Rat IL-1 Alpha/IL-1F1/IL1A ELISA Kit PicoKine® | Boster EK0390 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat IL-1 Alpha/IL-1F1/IL1A ELISA Kit PicoKine®

catalog :

EK0390

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0390

Product Name :

Rat IL-1 Alpha/IL-1F1/IL1A ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat IL-1 Alpha ELISA Kit PicoKine® (96 Tests). Quantitate Rat Il1a in cell culture supernatants and serum. Sensitivity: 0.5pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

IL1A

Uniprot ID :

P16598

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S115-S270

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

4.69 pg/ml - 300 pg/ml

Sensitivity :

<0.5 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-1 alpha

Synonyms :

Interleukin-1 alpha;IL-1 alpha;Il1a;

Protein Name :

Interleukin-1 alpha

Molecular Weight :

30856 MW

Protein Function :

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Subcellular Localization :

Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Background :

Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. IL-1 alpha has been implicated in the pathogenesis of infectious, autoimmune and inflammatory diseases. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which is described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors.1 The human interleukin 1 alpha gene is assigned to chromosome 2. Genetic polymorphisms at interleukin (IL)-1alpha and IL-1beta have been recently suggested to be associated with severity of adult periodontitis. The murine IL-1 alpha and IL-1 beta genes encode structurally and evolutionarily related cytokines that exert a regulatory role in numerous physiological processes including hemopoiesis. The standard product used in this kit is recombinant rat IL-1alpha with the molecular mass of 18kDa.

Research Category :

Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology