Human IGFBP4 PicoKine® ELISA Kit | Boster EK0388 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IGFBP4 PicoKine® ELISA Kit

catalog :

EK0388

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0388

Product Name :

Human IGFBP4 PicoKine® ELISA Kit

Size :

96 wells/kit, with removable strips.

Description :

Human IGFBP4 PicoKine® ELISA Kit (96 Tests). Quantitate Human IGFBP4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IGFBP4

Uniprot ID :

P22692

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D22-E258

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

500 pg/ml - 32,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Insulin-like growth factor-binding protein 4

Synonyms :

Insulin-like growth factor-binding protein 4;IBP-4;IGF-binding protein 4;IGFBP-4;IGFBP4;IBP4;

Protein Name :

Insulin-like growth factor-binding protein 4

Molecular Weight :

27934 MW

Protein Function :

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular Localization :

Secreted.

Background :

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4gene. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. In addition, IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells.

Research Category :

Angiogenesis, Cardiovascular, Cytoskeleton / Ecm, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lipid Signaling, Signal Transduction, Signaling Pathway, Structures