Human IGFBP2 ELISA Kit PicoKine® | Boster EK0384 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IGFBP2 ELISA Kit PicoKine®

catalog :

EK0384

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, et al. Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PLoS ONE. 2013;8:e74973 pubmed publisher

image

image 1 :

Human IGFBP2 PicoKine ELISA Kit standard curve

product information

SKU :

EK0384

Product Name :

Human IGFBP2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human IGFBP2 ELISA Kit PicoKine® (96 Tests). Quantitate Human IGFBP2 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IGFBP2

Uniprot ID :

P18065

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E40-Q328

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Insulin-like growth factor-binding protein 2

Synonyms :

Insulin-like growth factor-binding protein 2;IBP-2;IGF-binding protein 2;IGFBP-2;IGFBP2;BP2, IBP2;

Protein Name :

Insulin-like growth factor-binding protein 2

Molecular Weight :

34814 MW

Protein Function :

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular Localization :

Secreted.

Sequence Similarities :

Contains 1 IGFBP N-terminal domain.

Background :

Insulin-like growth factor-binding protein 2 (IGFBP2), also called IBP2, is a protein that in humans is encoded by the IGFBP2 gene. It is mapped to 2q35. By structural analysis, it showed that the IGFBP2 gene consists of 4 exons with 3 introns of lengths 27.0, 1.0, and 1.9 kb. IGFBP2 secreted by metastatic cells recruits endothelia by modulating IGF1 mediated activation of the IGF type-I receptor on endothelial cells. The IGFBP2/IGF1/IGF1R and GAS6/MERTK signaling pathways are regulators of cancer-mediated endothelial recruitment.

Research Category :

Cancer, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Signal Transduction

more info or order :

Boster product webpage