Rabbit IGF-2 ELISA Kit PicoKine® | Boster EK0379-RB product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rabbit IGF-2 ELISA Kit PicoKine®

catalog :

EK0379-RB

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0379-RB

Product Name :

Rabbit IGF-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rabbit IGF-2 ELISA Kit PicoKine® (96 Tests). Quantitate Rabbit IGF2 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 2pg/ml.

Reactivity :

Rabbit

Application :

ELISA

Gene Name :

IGF2

Uniprot ID :

P01344

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A25-E91

Cross-reactivity :

There is no detectable cross-reactivity with IGF-1.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Insulin-like growth factor II

Synonyms :

Insulin-like growth factor II;IGF-II;Somatomedin-A;T3M-11-derived growth factor;Insulin-like growth factor II;Insulin-like growth factor II Ala-25 Del;Preptin;IGF2;PP1446;

Protein Name :

Insulin-like growth factor II

Molecular Weight :

20140 MW

Protein Function :

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.

Subcellular Localization :

Secreted.

Sequence Similarities :

Belongs to the insulin family.

Background :

Insulin-like growth factor II is also known as somatomedin A. IGF-2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is paternally expressed in the fetus and placenta. IGF-II is a mitogen for many cell types and an important modulator of muscle growth and differentiation. IGF-II gene is prevalently expressed during prenatal development and its gene activity is regulated by genomic imprinting, in that the allele inherited from the father is active and the allele inherited from the mother is inactive in most normal tissues. IGF-II appears to be induced by placental lactogen during prenatal development. It is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. The rabbit IGF-II gene is located on chromosome 11. The standard product used in this kit is recombinant rabbit IGF-2, consisting of 67 amino acids in mature form with the molecular mass of 7.5KDa. IGF-1 and IGF-2 share high homology.

Research Category :

Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction