ELISA/assay

Chinese Hamster IGF-1 ELISA Kit PicoKine®

EK0377-HA

96 wells/kit, with removable strips.

369 USD

Chinese Hamster IGF-1 ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369 USD

Chinese Hamster IGF-1 ELISA Kit PicoKine® (96 Tests). Quantitate Chinese Igf1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 5pg/ml.

Hamster

ELISA

Igf1

P08025

Expression system for standard: E.coli; Immunogen sequence: G49-A118

There is detectable cross-reactivity with IGF-2< 1%.

62.5 pg/ml - 4,000 pg/ml

<5 pg/ml

cell culture supernatants, serum and plasma (heparin, EDTA)

monoclonal antibody from mouse, polyclonal antibody from goat specific for IGF-1

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Insulin-like growth factor I

Insulin-like growth factor I;IGF-I;Somatomedin;Igf1;Igf-1;

Insulin-like growth factor I

17079 MW

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity).

Secreted.

Belongs to the insulin family.

Insulin-like growth factor 1 (IGF-1) that was once called somatomedin C, is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. Chinese hamster IGF1 is a single chain 70-amino acid polypeptide cross-linked by 3 disulfide bridges, with a calculated molecular mass of 7.6 kD. The IGF1 gene, mapped on 12q22-q24.1, contains 5 exons. Exons 1-4 encode the 195-amino acid precursor (IGF1B), and exons 1, 2, 3, and 5 encode the 153-residue peptide (IGF1A). The structure of IGF1 resembles that of IGF2. And the IGF1 and IGF2 genes have complex structures with multiple promoters. The expression of both genes is regulated at the levels of transcription, RNA processing, and translation. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Moreover, approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). Furthermore, IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction