Human ICAM-1 / CD54 ELISA Kit PicoKine® | Boster EK0370 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ICAM-1 / CD54 ELISA Kit PicoKine®

catalog :

EK0370

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0370

Product Name :

Human ICAM-1 / CD54 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ICAM-1 / CD54 ELISA Kit PicoKine® (96 Tests). Quantitate Human ICAM1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ICAM1

Uniprot ID :

P05362

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q28-E480

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Intercellular adhesion molecule 1

Synonyms :

Intercellular adhesion molecule 1;ICAM-1;Major group rhinovirus receptor;CD54;ICAM1;

Protein Name :

Intercellular adhesion molecule 1

Molecular Weight :

57825 MW

Protein Function :

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Sequence Similarities :

Belongs to the immunoglobulin superfamily. ICAM family.

Background :

Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human intercellular adhesion molecule-1 (ICAM-1) is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). ICAM-1 is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.1

Research Category :

Adaptive Immunity, Atherosclerosis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Lymphocytic Lineage, Vascular Inflammation