Mouse G-CSF / CSF3 ELISA Kit PicoKine® | Boster EK0361 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse G-CSF / CSF3 ELISA Kit PicoKine®

catalog :

EK0361

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0361

Product Name :

Mouse G-CSF / CSF3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse G-CSF / CSF3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Csf3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 4pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CSF3

Uniprot ID :

P09920

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: V31-A208

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<4 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Granulocyte colony-stimulating factor

Synonyms :

Granulocyte colony-stimulating factor;G-CSF;Csf3;Csfg;

Protein Name :

Granulocyte colony-stimulating factor

Molecular Weight :

22421 MW

Protein Function :

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Subcellular Localization :

Secreted.

Background :

Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of hormone-like glycoprotein that regulates hematopoietic cell proliferation and differentiation, and it almost exclusively stimulates the colony formation of granulocytes from committed precursor cells in semi-solid agar culture. G-CSF is also termed colony stimulating factor-3, and a single gene of which codes for a 177 or 180 amino acid mature protein of molecular weight 19,600. Functionally, it specifically stimulates the proliferation and differentiation of the progenitor cells for granulocytes. The effect of G-CSF on myeloid leukemias is unique among colony stimulating factors in driving the leukemic cells from a self-renewing malignant state to a mature differentiated phenotype with the concomitant loss of tumorigenicity. Besides, it also prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. The recombinant form of hG-CSF is capable of supporting neutrophil proliferation in a CFU-GM assay as well as early erythroid colonies and mixed colony formation. Human gene coding for G-CSF is assigned to the q21-q22 region of chromosome 17.3 The standard product used in this kit is recombinant Mouse G-csf, consisting of 179 amino acids with the molecular mass of 19KDa.

Research Category :

Angiogenesis, Cancer, Cytokines, Immunology, Innate Immunity, Invasion/Microenvironment