Rat Fractalkine/CX3CL1 ELISA Kit PicoKine® | Boster EK0358 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat Fractalkine/CX3CL1 ELISA Kit PicoKine®

catalog :

EK0358

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Zheng B, Cheng D, Chen X, Yang L, Xia X, Su Q. [The change of fractalkine in lung tissue of rat with hypoxic pulmonary hypertension]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008;39:227-30 pubmed

image

image 1 :

Rat Fractalkine PicoKine ELISA Kit standard curve

product information

SKU :

EK0358

Product Name :

Rat Fractalkine/CX3CL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Rat Fractalkine/CX3CL1 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Cx3cl1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

CX3CL1

Uniprot ID :

O55145

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q25-T334

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Fractalkine

Synonyms :

Fractalkine;C-X3-C motif chemokine 1;CX3C membrane-anchored chemokine;Neurotactin;Small-inducible cytokine D1;Processed fractalkine;Cx3cl1;Acc1, Fkn, Scyd1;

Protein Name :

Fractalkine

Molecular Weight :

41977 MW

Protein Function :

The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Highest levels in brain (neurons). Significant levels in kidney, heart, lung and adrenal gland.

Background :

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22. It can act as a mediator of smooth muscle cell migration in human atherosclerosis, rather than mediate inflammatory cell recruitment.

Research Category :

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation

more info or order :

Boster product webpage