Human Fractalkine/CX3CL1 ELISA Kit PicoKine® | Boster EK0356 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Fractalkine/CX3CL1 ELISA Kit PicoKine®

catalog :

EK0356

quantity :

96 wells/kit, with removable strips.

price :

400 USD

more info or order :

Boster product webpage

citations: 2

Reference
Lee J, Kwok S, Jung S, Lee J, Lee J, Baek S, et al. Role of fractalkine in the pathogenesis of primary SjÃ¶gren syndrome: increased serum levels of fractalkine, its expression in labial salivary glands, and the association with clinical manifestations. J Rheumatol. 2014;41:2425-38 pubmed publisher
Ghazanfari T, Yaraee R, Kariminia A, Ebtekar M, Faghihzadeh S, Vaez Mahdavi M, et al. Alterations in the serum levels of chemokines 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study. Int Immunopharmacol. 2009;9:1471-6 pubmed publisher

image

image 1 :

Human Fractalkine/CX3CL1 PicoKine ELISA Kit standard curve

product information

SKU :

EK0356

Product Name :

Human Fractalkine/CX3CL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

400 USD

Description :

Human Fractalkine/CX3CL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CX3CL1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CX3CL1

Uniprot ID :

A0N0N7

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q25-R339

Cross-reactivity :

There is detectable cross-reactivity with Eotaxin, MCP-1, MCP-2, 6Ckine, MARC< 0.2%.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

chemokine (C-X3-C motif) ligand 1

Synonyms :

Chemokine (C-X3-C motif) ligand 1 ;cDNA, FLJ94424, Homo sapiens chemokine (C-X3-C motif) ligand 1 (CX3CL1), mRNA ;CX3CL1 ;hCG_15105 ;

Protein Name :

Fractalkine

Molecular Weight :

42203 MW

Background :

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22. It can act as a mediator of smooth muscle cell migration in human atherosclerosis, rather than mediate inflammatory cell recruitment.

Research Category :

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation

more info or order :

Boster product webpage