Monkey primate FGF1/Fgf Acidic ELISA Kit PicoKine® | Boster EK0339-PR product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Monkey primate FGF1/Fgf Acidic ELISA Kit PicoKine®

catalog :

EK0339-PR

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0339-PR

Product Name :

Monkey primate FGF1/Fgf Acidic ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Monkey primate FGF1/Fgf Acidic ELISA Kit PicoKine® (96 Tests). Quantitate Monkey FGF1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Monkey

Application :

ELISA

Gene Name :

FGF1

Uniprot ID :

P05230

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A2-D155

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Fibroblast growth factor 1

Synonyms :

Fibroblast growth factor 1;FGF-1;Acidic fibroblast growth factor;aFGF;Endothelial cell growth factor;ECGF;Heparin-binding growth factor 1;HBGF-1;FGF1;FGFA;

Protein Name :

Fibroblast growth factor 1

Molecular Weight :

17460 MW

Protein Function :

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

Subcellular Localization :

Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu (2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.

Tissue Specificity :

Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

Background :

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Signal Transduction