Human Eotaxin / CCL11 ELISA Kit PicoKine® | Boster EK0329 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Eotaxin / CCL11 ELISA Kit PicoKine®

catalog :

EK0329

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 2

Reference
Wang L, Chien C, Tai C, Chiang F, Chen J. Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps. Kaohsiung J Med Sci. 2015;31:63-9 pubmed publisher
Chen W, Paulus B, Shu D, Wilson -, Chadwick V. Increased serum levels of eotaxin in patients with inflammatory bowel disease. Scand J Gastroenterol. 2001;36:515-20 pubmed

image

image 1 :

Human Eotaxin PicoKine ELISA Kit standard curve

product information

SKU :

EK0329

Product Name :

Human Eotaxin / CCL11 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human Eotaxin / CCL11 ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL11 in cell culture supernatants, serum and plasma (citrate, EDTA). Sensitivity: 2pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL11

Uniprot ID :

P51671

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G24-P97

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (citrate, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Eotaxin

Synonyms :

Eotaxin;C-C motif chemokine 11;Eosinophil chemotactic protein;Small-inducible cytokine A11;CCL11;SCYA11;

Protein Name :

Eotaxin

Molecular Weight :

10732 MW

Protein Function :

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Subcellular Localization :

Secreted.

Sequence Similarities :

Belongs to the intercrine beta (chemokine CC) family.

Background :

Eotaxin, also known as CCL11, is a potent inducer of eosinophil chemotaxis and is considered as a selective ligand of the CC chemokine receptor 3 (CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. Eotaxin is assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. The gene maps to chromosome 17 and is expressed constitutively at high levels in small intestine and colon, and at lower levels in various other tissues. The deduced mature protein sequence is 66% identical to human monocyte chemoattractant protein-1, and 60% identical to guinea pig eotaxin. Recombinant human eotaxin produced in insect cells induces a calcium flux response in normal human eosinophils, but not in neutrophils or monocytes. The human eotaxin gene is cloned and found to be 61.8 and 63.2% identical at the amino acid level to guinea pig and mouse eotaxin.

Research Category :

Chemokines, Immunology, Innate Immunity

more info or order :

Boster product webpage