Mouse BMP-4 ELISA Kit PicoKine® | Boster EK0316 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse BMP-4 ELISA Kit PicoKine®

catalog :

EK0316

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Chen W, Yang J, Wu Y, Li L, Li R, Chang Y, et al. IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury. Exp Mol Med. 2018;50:36 pubmed publisher

product information

SKU :

EK0316

Product Name :

Mouse BMP-4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Mouse BMP-4 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Bmp4 in bone tissue, cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Predicted Reactivity :

Bovine, Monkey

Application :

ELISA

Gene Name :

Bmp4

Uniprot ID :

P21275

Immunogen :

Expression system for standard: CHO; Immunogen sequence: S293-R408

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

bone tissue, cell culture supernatants and serum

Capture/Detection Antibodies :

a monoclonal antibody from rat, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Bone morphogenetic protein 4

Synonyms :

Bone morphogenetic protein 4;BMP-4;Bone morphogenetic protein 2B;BMP-2B;Bmp4;Bmp-4, Dvr-4;

Protein Name :

Bone morphogenetic protein 4

Molecular Weight :

46497 MW

Protein Function :

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix.

Background :

Bone morphogenetic protein 4 is a protein that in humans is encoded by the BMP4 gene which is located to 14q22-q23. The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. Also, BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Developmental Biology, Growth Factors, Growth Factors/Hormones, Nervous System Development, Organogenesis, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Tgf Beta

more info or order :

Boster product webpage