Bovine BDNF ELISA Kit PicoKine® | Boster EK0307-BV product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Bovine BDNF ELISA Kit PicoKine®

catalog :

EK0307-BV

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Koeva Y, Sivkov S, Akabaliev V, Ivanova R, Deneva T, Grozlekova L, et al. Brain-derived neurotrophic factor and its serum levels in schizophrenic patients. Folia Med (Plovdiv). 2014;56:20-3 pubmed

product information

SKU :

EK0307-BV

Product Name :

Bovine BDNF ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Bovine BDNF ELISA Kit PicoKine® (96 Tests). Quantitate Bovine BDNF in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 15pg/ml.

Reactivity :

Bovine

Application :

ELISA

Gene Name :

BDNF

Uniprot ID :

P23560

Immunogen :

Expression system for standard: NS0; Immunogen sequence: H129-R247

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from mouse, monoclonal antibody from mouse

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Brain-derived neurotrophic factor

Synonyms :

Brain-derived neurotrophic factor;BDNF;Abrineurin;BDNF;

Protein Name :

Brain-derived neurotrophic factor

Molecular Weight :

27818 MW

Protein Function :

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Subcellular Localization :

Secreted.

Tissue Specificity :

Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.

Sequence Similarities :

Belongs to the NGF-beta family.

Background :

Brain-derived neurotrophic factor (BDNF) is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is a secreted protein with the molecular weight of 27.8kDa, consisting of 247 amino acids. It is known to promote neuronal survival and differentiation. BDNF shares substantial amino acid sequence identity with nerve growth factor (NGF). BDNF and neurotrophin-3 (NT-3) are two recently cloned neurotrophic factors that are homologous to NGF. mRNA products of the BDNF and NT-3 genes are detected in the adult Bovine brain, suggesting that these proteins are involved in the maintenance of the adult nervous system. BDNF and other neurotrophins are critically involved in long-term potentiation (LTP). BDNF-mediated LTP is induced postsynaptically. BDNF has trophic effects on serotonergic (5-HT) neurons in the central nervous system. BDNF has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state. It plays a role in treating breathing disorders such as respiratory insufficiency after spinal injury. The mature form of BDNF is identical in all mammals examined, and the gene encoding Bovine BDNF to chromosome 11, band p13.

Research Category :

Alzheimer'S Disease, Atherosclerosis, Cardiovascular, Diabetes, Diabetes Associated, Growth And Development, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Obesity

more info or order :

Boster product webpage