Human Amphiregulin(AR) / AREG ELISA Kit PicoKine® | Boster EK0304 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Amphiregulin(AR) / AREG ELISA Kit PicoKine®

catalog :

EK0304

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 2

Reference
PETERSON E, Pectasides E, Shabbeer S, Wiechmann L, Sparano J, Kenny P. Evaluation of serum Amphiregulin levels in breast cancer patients and cancer-free controls. Exp Hematol Oncol. 2013;2:25 pubmed publisher
Liu N, Ma Y, Li R, Jin H, Li M, Huang X, et al. Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols. Endocrine. 2012;42:708-16 pubmed publisher

image

image 1 :

Human Amphiregulin(AR) PicoKine ELISA Kit standard curve

product information

SKU :

EK0304

Product Name :

Human Amphiregulin(AR) / AREG ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human Amphiregulin (AR) / AREG ELISA Kit PicoKine® (96 Tests). Quantitate Human AREG in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva and human milk. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

AREG

Uniprot ID :

P15514

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S101-K198

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Amphiregulin

Synonyms :

Amphiregulin;AR;Colorectum cell-derived growth factor;CRDGF;AREG;SDGF;AREGB;

Protein Name :

Amphiregulin

Molecular Weight :

27895 MW

Protein Function :

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subcellular Localization :

Membrane; Single-pass membrane protein.

Sequence Similarities :

Belongs to the amphiregulin family.

Background :

Amphiregulin, also known as AREG, is a protein that in humans is encoded by the AREG gene. The protein encoded by this gene is a member of the epidermal growth factor family. This gene is mapped to 4q13.1. It is an autocrine growth factor as well as a mitogen forastrocytes, Schwann cells, fibroblasts. Amphiregulin is related to toepidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor to promote the growth of normal epithelial cells. It has been found that transgene integration and subsequent expression of Amphiregulin in basal keratinocytes correlated with a psoriasis-like skin phenotype, and its expression was increased in parallel with typical Th2 cytokines. Amphiregulin is also an important paracrine mediator of estrogen function specifically required for puberty-induced ductal elongation but not for any earlier or later developmental stages, and it can enhance resistance to nematodes.

Research Category :

Cancer, Growth Factors, Growth Factors/Hormones, Signal Transduction

more info or order :

Boster product webpage