Anti-PDI Antibody (Monoclonal, 1D3), PE Conjugated | Boster E02335 product information

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product summary

company name :

Boster

product type :

other

product name :

Anti-PDI Antibody (Monoclonal, 1D3), PE Conjugated

catalog :

E02335

quantity :

200 ug/vial

product information

sku :

E02335

status :

Enabled

name :

Anti-PDI Antibody (Monoclonal, 1D3), PE Conjugated

category name :

Monoclonal Antibodies, IHC ICC IF Antibodies

gene name :

P4hb

price various sizes :

200ug / $474 200ug+Free HRP Secondary BA1050 / $474 200ug+Free Biotin Secondary BA1001 / $474

clonality :

Monoclonal

clone number :

1D3

concentration :

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

conjugate :

contents :

Each vial contains 0.09% sodium azide.

description :

Monoclonal, 1D3 antibody for PDI/P4hb detection. Host: Mouse.Size: 200ug/vial. Tested applications: Flow Cytometry. Reactive species: Human. PDI/P4hb information: Molecular Weight: 56951 MW; Subcellular Localization: Endoplasmic reticulum . Endoplasmic reticulum lumen . Melanosome . Cell membrane ; Peripheral membrane protein . Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum.

short description :

Mouse Anti-PDI Antibody (Monoclonal, 1D3), PE Conjugated for P4hb detectiontested for Flow Cytometry, IHC in Human, Mouse, Rat.

size :

200 ug/vial

uniprot id :

P04785

host :

Mouse

immunogen :

Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI.

form :

Liquid

purification :

Protein G affinity purified.

application details :

Flow Cytometry, 1:100, Human, Mouse, Rat

applications :

Flow Cytometry

reactivity :

Human, Mouse, Rat

image labels :

Flow cytometry analysis of 10 6 Jurkat cells stained using PDI mAb (1D3), R-Phycoerythrin Conjugate at a concentration of 10ug/ml.

research category :

Cancer, Cancer Metabolism, Chaperones, Collagen, Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Lipids And Lipoproteins, Pathways And Processes, Protein Trafficking, Signal Transduction

synonyms :

Protein disulfide-isomerase;PDI;5.3.4.1;Cellular thyroid hormone-binding protein;Prolyl 4-hydroxylase subunit beta;P4hb;Pdia1;

gene full name :

Protein disulfide-isomerase

molecular weight :

56951 MW

protein function :

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

subcellular localization :

Endoplasmic reticulum . Endoplasmic reticulum lumen . Melanosome . Cell membrane ; Peripheral membrane protein . Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum.

protein name :

Protein disulfide-isomerase (P4hb)

last modified :

2/6/19 22:57